Reactome | PRODH2 oxidises HPRO to 1PYR-5COOH

PRODH2 oxidises HPRO to 1PYR-5COOH

Stable Identifier

R-HSA-8955817

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

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The catabolism of trans-4-hydroxy-L-proline (HPRO) and proline (L-Pro) (from endogenous and dietary sources of collagen) makes a significant contribution to the glyoxylate pool in humans. The dehydrogenation (oxidation) of HPRO/L-Pro to L-1-pyrroline-5-carboxylate (1PYR-5COOH) coupled to the conversion of FAD to FADH2 is the first step in proline catabolism. Proline dehydrogenases (PRODHs), located at the inner mitochondrial membrane mediate this reaction. Whereas PRODH prefers L-Pro as substrate, PRODH2 has a clear preference for HPRO (Summitt et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25697095	Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria Holmes, RP, Johnson, LC, Summitt, CB, Parsonage, D, Lowther, WT, Jönsson, TJ	Biochem. J.	2015