Reactome | PRODH2 oxidises HPRO to 1PYR-3OH-5COOH

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PRODH2 oxidises HPRO to 1PYR-3OH-5COOH Show undefined attributes

catalystActivity	[CatalystActivity:11103405] proline dehydrogenase activity of PRODH2 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11103407
displayName	PRODH2 oxidises HPRO to 1PYR-3OH-5COOH
eventOf	[Pathway:R-SCE-70688] Proline catabolism - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Homo sapiens
input	[SimpleEntity:R-ALL-113597] FAD [mitochondrial inner membrane] [SimpleEntity:R-ALL-6784215] HPRO [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PRODH2 oxidises HPRO to 1PYR-3OH-5COOH a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
output	[SimpleEntity:R-ALL-9929425] 1PYR-3OH-5COOH [mitochondrial matrix] [SimpleEntity:R-ALL-164934] FADH2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-8955817
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-70688] Proline catabolism
(inferredTo)	[Reaction:R-HSA-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH

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