HPRO (4-hydroxy-L-proline) is oxidized to 1PYR-3OH-5COOH (L-...

created [InstanceEdit:8955828] Jassal, Bijay, 2017-01-13
dbId 8955829
displayName HPRO (4-hydroxy-L-proline) is oxidized to 1PYR-3OH-5COOH (L-...
modified [InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
schemaClass Summation
text HPRO (4-hydroxy-L-proline) is oxidized to 1PYR-3OH-5COOH (L-1-pyrroline-3-hydroxy-5-carboxylate), coupled to the reduction of FAD to FADH2. Hydroxyproline dehydrogenase (PRODH2) located at the inner mitochondrial membrane mediates this reaction. Whereas PRODH prefers L-Pro as substrate, PRODH2 has a clear preference for HPRO (Summitt et al. 2015).
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