Reactome | Transcriptional Regulation by E2F6

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Transcriptional Regulation by E2F6 Show undefined attributes

authored	[InstanceEdit:8954169] Orlic-Milacic, Marija, 2017-01-05
created	[InstanceEdit:8953751] Orlic-Milacic, Marija, 2016-12-27
dbId	8953750
displayName	Transcriptional Regulation by E2F6
doi	10.3180/R-HSA-8953750.1
edited	[InstanceEdit:9007684] Orlic-Milacic, Marija, 2017-05-31
eventOf	[Pathway:R-HSA-212436] Generic Transcription Pathway - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:396779] negative regulation of G0 to G1 transition
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8953111] E2F6 binds TFDP1 - Homo sapiens [Reaction:R-HSA-8954056] E2F6 binds TFDP2 - Homo sapiens [Reaction:R-HSA-8953115] E2F6:TFDP1 binds to MGA:MAX - Homo sapiens [Reaction:R-HSA-8953418] EHMT1:EHMT2 complex binds E2F6.com-1 core - Homo sapiens [Reaction:R-HSA-9007283] CBX3 and PRC1.6 associate with E2F6.com-1 - Homo sapiens [Reaction:R-HSA-8953452] E2F6.com-1 complex binds the E2F1 gene promoter - Homo sapiens [Reaction:R-HSA-9007220] E2F6:TFDP1/2 binds the E2F1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8953556] E2F1 gene transcription is inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-8954082] E2F6 binds the PRC1 complex - Homo sapiens [Reaction:R-HSA-8954117] E2F6:TFDP1 binds EPC1 - Homo sapiens [Reaction:R-HSA-8954110] E2F6:TFDP1:EPC1 binds the PRC2 complex - Homo sapiens [Reaction:R-HSA-9007447] E2F6 forms the PRC1L4 complex - Homo sapiens [Reaction:R-HSA-9007467] The PRC1L4 complex binds the CDC7 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007462] CDC7 gene expression is repressed by the PRC1L4 complex - Homo sapiens [Reaction:R-HSA-9007464] The PRC1L4 complex binds the UXT gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007465] UXT gene expression is repressed by the PRC1L4 complex - Homo sapiens [Reaction:R-HSA-9007514] E2F1 binds APAF1 gene promoter - Homo sapiens [Reaction:R-HSA-9007522] E2F6 binds APAF1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007496] APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-9007539] CHEK1 phosphorylates E2F6 - Homo sapiens [Reaction:R-HSA-9007546] E2F6 binds RAD51 gene promoter - Homo sapiens [Reaction:R-HSA-9007561] E2F1 binds RAD51 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007582] RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-9007591] E2F6 binds RRM2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961982] RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-9007606] E2F6 binds BRCA1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007605] BRCA1 gene expression is inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-9007615] E2F6 binds RBBP8 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007625] RBBP8 gene expression is inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-9007631] E2F6 binds RBBP4 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007640] RBBP4 gene expression is inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-9007647] E2F6 binds CBX5 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9007646] CBX5 gene expression is inhibited by E2F6 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8953102] A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells [LiteratureReference:8953108] Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6 [LiteratureReference:8954073] E2F-6, a member of the E2F family that can behave as a transcriptional repressor [LiteratureReference:8954090] E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription [LiteratureReference:8954129] A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription [LiteratureReference:9007059] Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6 [LiteratureReference:9007074] L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure [LiteratureReference:9007077] E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 [LiteratureReference:9007091] Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription [LiteratureReference:9007093] Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Transcriptional Regulation by E2F6
orthologousEvent	[Pathway:R-DDI-8953750] Transcriptional Regulation by E2F6 - Dictyostelium discoideum [Pathway:R-CEL-8953750] Transcriptional Regulation by E2F6 - Caenorhabditis elegans [Pathway:R-DME-8953750] Transcriptional Regulation by E2F6 - Drosophila melanogaster [Pathway:R-GGA-8953750] Transcriptional Regulation by E2F6 - Gallus gallus [Pathway:R-XTR-8953750] Transcriptional Regulation by E2F6 - Xenopus tropicalis [Pathway:R-DRE-8953750] Transcriptional Regulation by E2F6 - Danio rerio [Pathway:R-SSC-8953750] Transcriptional Regulation by E2F6 - Sus scrofa [Pathway:R-MMU-8953750] Transcriptional Regulation by E2F6 - Mus musculus [Pathway:R-RNO-8953750] Transcriptional Regulation by E2F6 - Rattus norvegicus [Pathway:R-CFA-8953750] Transcriptional Regulation by E2F6 - Canis familiaris [Pathway:R-BTA-8953750] Transcriptional Regulation by E2F6 - Bos taurus
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005633] Herlihy, Anna, 2017-05-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8953750
summation	[Summation:8954043] E2F6, similar to other E2F proteins, possesses the DNA bindi...

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[Pathway:R-HSA-212436] Generic Transcription Pathway

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