Reactome | E2F6 binds RAD51 gene promoter

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E2F6 binds RAD51 gene promoter Show undefined attributes

authored	[InstanceEdit:9007684] Orlic-Milacic, Marija, 2017-05-31
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9007544] Orlic-Milacic, Marija, 2017-05-31
dbId	9007546
displayName	E2F6 binds RAD51 gene promoter
edited	[InstanceEdit:9007684] Orlic-Milacic, Marija, 2017-05-31
eventOf	[Pathway:R-HSA-8953750] Transcriptional Regulation by E2F6 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9007582] RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens
input	[CandidateSet:R-HSA-9007225] E2F6:(TFDP1,TFDP2) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9007545] RAD51 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9007091] Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F6 binds RAD51 gene promoter
output	[Complex:R-HSA-9007547] E2F6:(TFDP1,TFDP2):RAD51 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8953111] E2F6 binds TFDP1 - Homo sapiens [Reaction:R-HSA-8954056] E2F6 binds TFDP2 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-9007560] Negative regulation by 'p-S317,S345-CHEK1 [nucleoplasm]'
regulationReference	[RegulationReference:9641986] Negative regulation by 'p-S317,S345-CHEK1 [nucleoplasm]' Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005633] Herlihy, Anna, 2017-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9007546
summation	[Summation:9007543] E2F6, presumably in complex with at least TFDP1 (DP-1) or TF...

Referrals

(hasEvent)	[Pathway:R-HSA-8953750] Transcriptional Regulation by E2F6
(precedingEvent)	[BlackBoxEvent:R-HSA-9007582] RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6