Reactome | E2F1 binds APAF1 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:9007684] Orlic-Milacic, Marija, 2017-05-31
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9007510] Orlic-Milacic, Marija, 2017-05-31
dbId	9007514
displayName	E2F1 binds APAF1 gene promoter
edited	[InstanceEdit:9007684] Orlic-Milacic, Marija, 2017-05-31
eventOf	[Pathway:R-HSA-8953750] Transcriptional Regulation by E2F6 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9007496] APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6791347] APAF1 gene [nucleoplasm] [Complex:R-HSA-9007512] E2F1:(TFDP1,TFDP2) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9007498] E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1 binds APAF1 gene promoter
output	[Complex:R-HSA-9007509] E2F1:(TFDP1,TFDP2):APAF1 gene [nucleoplasm]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005633] Herlihy, Anna, 2017-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9007514
summation	[Summation:9007513] E2F1, presumably in complex with TFDP1 or TFDP2, binds the p...

(hasEvent)	[Pathway:R-HSA-8953750] Transcriptional Regulation by E2F6
(precedingEvent)	[BlackBoxEvent:R-HSA-9007496] APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6

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