Reactome | SMURFs ubiquitinate RUNX3

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SMURFs ubiquitinate RUNX3 Show undefined attributes

catalystActivity	[CatalystActivity:10899981] ubiquitin protein ligase activity of SMURF [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10899983
displayName	SMURFs ubiquitinate RUNX3
eventOf	[Pathway:R-DME-8941858] Regulation of RUNX3 expression and activity - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8952419] SMURFs ubiquitinate RUNX3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-8865393] run [nucleoplasm] 3 × [DefinedSet:R-DME-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SMURFs ubiquitinate RUNX3
output	[EntityWithAccessionedSequence:R-DME-8952417] run [nucleoplasm]
precedingEvent	[Reaction:R-DME-8937814] RUNX3 translocates to the nucleus - Drosophila melanogaster
regulatedBy	[NegativeRegulation:10899984] Negative regulation by 'EP300 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8952419
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8941858] Regulation of RUNX3 expression and activity
(inferredTo)	[Reaction:R-HSA-8952419] SMURFs ubiquitinate RUNX3

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