SMURFs ubiquitinate RUNX3

Stable Identifier
R-HSA-8952419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMURFs ubiquitinate RUNX3
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SMURF1 and SMURF2 polyubiquitinate RUNX3 on unknown lysine residues, possibly K148, K186 and K192, targeting it for degradation. The interaction between SMURFs and RUNX3 involves the PY motif of RUNX3 and the WW domain of SMURFs. Acetylation of RUNX3 by EP300 (p300) prevents SMURF-mediated ubiquitination of RUNX3, thus increasing RUNX3 protein stability (Jin et al. 2004).
Literature References
PubMed ID Title Journal Year
15138260 Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation

Jeon, EJ, Jin, YH, Lee, YH, Li, QL, Lee, KY, Bae, SC, Kim, WJ, Choi, JK

J. Biol. Chem. 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of SMURF [nucleoplasm]

Physical Entity
SMURF [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
This event is regulated
Negatively by
Regulator
EP300 [nucleoplasm] (Homo sapiens)
Orthologous Events
SMURFs ubiquitinate RUNX3 (Bos taurus)
SMURFs ubiquitinate RUNX3 (Canis familiaris)
SMURFs ubiquitinate RUNX3 (Danio rerio)
SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)
SMURFs ubiquitinate RUNX3 (Gallus gallus)
SMURFs ubiquitinate RUNX3 (Mus musculus)
SMURFs ubiquitinate RUNX3 (Rattus norvegicus)
SMURFs ubiquitinate RUNX3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-15)
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