Reactome | Regulation of RUNX3 expression and activity

Schema > Pathway > Entries

Regulation of RUNX3 expression and activity Show undefined attributes

authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
created	[InstanceEdit:8941857] Orlic-Milacic, Marija, 2016-10-06
dbId	8941858
displayName	Regulation of RUNX3 expression and activity
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf	[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8937814] RUNX3 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-8937792] RUNX3 binds SRC - Homo sapiens [Reaction:R-HSA-8937807] SRC phosphorylates RUNX3 - Homo sapiens [Reaction:R-HSA-8865454] CBFB binds RUNX3 - Homo sapiens [Reaction:R-HSA-8952371] MDM2 binds RUNX3 - Homo sapiens [Reaction:R-HSA-8952382] MDM2 polyubiquitinates RUNX3 - Homo sapiens [BlackBoxEvent:R-HSA-8952399] Polyubiquitinated RUNX3 translocates to the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-8952408] Polyubiquitinated RUNX3 is degraded by the proteasome - Homo sapiens [Reaction:R-HSA-8952419] SMURFs ubiquitinate RUNX3 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8865440] CBF? stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression [LiteratureReference:8937789] Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm [LiteratureReference:8941878] Pim-1 kinase phosphorylates and stabilizes RUNX3 and alters its subcellular localization [LiteratureReference:8952434] RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma [LiteratureReference:8952664] MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer [LiteratureReference:8952668] MicroRNA-130b functions as a tumor suppressor by regulating RUNX3 in epithelial ovarian cancer [LiteratureReference:8951914] Structure and regulated expression of mammalian RUNX genes [LiteratureReference:8952836] Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells [LiteratureReference:8952372] Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination [LiteratureReference:8951953] Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Regulation of RUNX3 expression and activity
orthologousEvent	[Pathway:R-CEL-8941858] Regulation of RUNX3 expression and activity - Caenorhabditis elegans [Pathway:R-DME-8941858] Regulation of RUNX3 expression and activity - Drosophila melanogaster [Pathway:R-GGA-8941858] Regulation of RUNX3 expression and activity - Gallus gallus [Pathway:R-DRE-8941858] Regulation of RUNX3 expression and activity - Danio rerio [Pathway:R-SSC-8941858] Regulation of RUNX3 expression and activity - Sus scrofa [Pathway:R-BTA-8941858] Regulation of RUNX3 expression and activity - Bos taurus [Pathway:R-CFA-8941858] Regulation of RUNX3 expression and activity - Canis familiaris [Pathway:R-RNO-8941858] Regulation of RUNX3 expression and activity - Rattus norvegicus [Pathway:R-MMU-8941858] Regulation of RUNX3 expression and activity - Mus musculus
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8941858
summation	[Summation:8941875] RUNX3, like other RUNX family members, is transcribed from t...

Referrals

(hasEvent)

[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3

Cite Us!