Reactome | IL12RB1:TYK2 [plasma membrane]

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IL12RB1:TYK2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-8950052] IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] - Homo sapiens [Complex:R-HSA-8950186] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] - Homo sapiens [Complex:R-HSA-447186] IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-447252] IL12RB1:TYK2 binds IL12RB2:JAK2 - Homo sapiens [BlackBoxEvent:R-HSA-447130] Interleukin-23 binds interleukin-23 receptor - Homo sapiens
created	[InstanceEdit:8950071] Duenas, Corina, 2016-12-02
dbId	8950046
displayName	IL12RB1:TYK2 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-447227] IL12RB1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-877348] TYK2 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredFrom	[Complex:R-MMU-8950055] Il12rb1:Tyk2 [plasma membrane] - Mus musculus
inferredTo	[Complex:R-MMU-8950046] IL12RB1:TYK2 [plasma membrane] - Mus musculus [Complex:R-RNO-8950046] IL12RB1:TYK2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-8950046] IL12RB1:TYK2 [plasma membrane] - Canis familiaris [Complex:R-BTA-8950046] IL12RB1:TYK2 [plasma membrane] - Bos taurus [Complex:R-SSC-8950046] IL12RB1:TYK2 [plasma membrane] - Sus scrofa [Complex:R-XTR-8950046] IL12RB1:TYK2 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-8950046] IL12RB1:TYK2 [plasma membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:8950054] Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases
maxDepth	2
name	IL12RB1:TYK2 Interleukin-12 receptors subunit beta 1: Tyrosin kinase 2
producedByEvent	[Reaction:R-HSA-8950057] IL12RB1 binds TYK2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8950046
summation	[Summation:8950038] The intracellular domain of human Interleukin-12 receptor su...

Referrals

(input)	[BlackBoxEvent:R-HSA-447130] Interleukin-23 binds interleukin-23 receptor [Reaction:R-HSA-447252] IL12RB1:TYK2 binds IL12RB2:JAK2
(hasComponent)	[Complex:R-HSA-447186] IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] [Complex:R-HSA-8950186] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] [Complex:R-HSA-8950052] IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane]
(inferredTo)	[Complex:R-MMU-8950055] Il12rb1:Tyk2 [plasma membrane]
(output)	[Reaction:R-HSA-8950057] IL12RB1 binds TYK2