Reactome | Interleukin-23 binds interleukin-23 receptor

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Interleukin-23 binds interleukin-23 receptor Show undefined attributes

authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
category	omitted
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:447133] Jupe, S, 2009-11-20
dbId	447130
displayName	Interleukin-23 binds interleukin-23 receptor
edited	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
eventOf	[Pathway:R-HSA-9020933] Interleukin-23 signaling - Homo sapiens
input	[Complex:R-HSA-447217] IL12B:IL23A [extracellular region] [Complex:R-HSA-8950046] IL12RB1:TYK2 [plasma membrane] [Complex:R-HSA-8950151] IL23R:JAK2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:447185] A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Interleukin-23 binds interleukin-23 receptor
orthologousEvent	[BlackBoxEvent:R-SSC-447130] Interleukin-23 binds interleukin-23 receptor - Sus scrofa [BlackBoxEvent:R-BTA-447130] Interleukin-23 binds interleukin-23 receptor - Bos taurus [BlackBoxEvent:R-CFA-447130] Interleukin-23 binds interleukin-23 receptor - Canis familiaris [BlackBoxEvent:R-RNO-447130] Interleukin-23 binds interleukin-23 receptor - Rattus norvegicus [BlackBoxEvent:R-MMU-447130] Interleukin-23 binds interleukin-23 receptor - Mus musculus
output	[Complex:R-HSA-447186] IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8950057] IL12RB1 binds TYK2 - Homo sapiens [Reaction:R-HSA-8950737] IL23R binds JAK2 - Homo sapiens [BlackBoxEvent:R-HSA-8950741] IL12B:IL23A translocates from ER lumen to extracellular space - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-447130
summation	[Summation:447263] Interleukin-23 (IL23) is a complex of Interleukin-23 subunit...
updateTrackers	[UpdateTracker:9783078] Update Tracker - [BlackBoxEvent:447130] Interleukin-23 binds interleukin-23 receptor - v57:[add_removeInput, modifyText] [UpdateTracker:9781610] Update Tracker - [BlackBoxEvent:447130] Interleukin-23 binds interleukin-23 receptor - v60:[add_removeInput, modifyText] [UpdateTracker:9781090] Update Tracker - [BlackBoxEvent:447130] Interleukin-23 binds interleukin-23 receptor - v61:[modifyText]

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[Pathway:R-HSA-9020933] Interleukin-23 signaling