Reactome | The intracellular domain of human Interleukin-12 receptor su...

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created	[InstanceEdit:8950071] Duenas, Corina, 2016-12-02
dbId	8950038
displayName	The intracellular domain of human Interleukin-12 receptor su...
literatureReference	[LiteratureReference:8950054] Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases [LiteratureReference:8950150] Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases
modified	[InstanceEdit:9006674] Jupe, Steve, 2017-05-17
schemaClass	Summation
text	The intracellular domain of human Interleukin-12 receptor subunit beta-1 (IL12RB1) but not the intracellular domain of Interleukin-12 receptor subunit beta-2 (IL12RB2) interacts directly with Non-receptor tyrosine-protein kinase (TYK2) (Zou et al. 1997) Inferred from mouse: TYK2 associates with IL12RB1. In the absence of TYK2, IL12RB1 can associate with Tyrosine-protein kinase JAK1 (JAK1) (Floss et al. 2016).

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