Reactome | IL12RB1:TYK2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-8950052] IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] - Sus scrofa [Complex:R-SSC-8950186] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] - Sus scrofa [Complex:R-SSC-447186] IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-447252] IL12RB1:TYK2 binds IL12RB2:JAK2 - Sus scrofa [BlackBoxEvent:R-SSC-447130] Interleukin-23 binds interleukin-23 receptor - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10479856
displayName	IL12RB1:TYK2 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-SSC-447227] IL12RB1 [plasma membrane] [EntityWithAccessionedSequence:R-SSC-877348] TYK2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8950046] IL12RB1:TYK2 [plasma membrane] - Homo sapiens
maxDepth	2
name	IL12RB1:TYK2
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-8950046
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-SSC-447130] Interleukin-23 binds interleukin-23 receptor [Reaction:R-SSC-447252] IL12RB1:TYK2 binds IL12RB2:JAK2
(hasComponent)	[Complex:R-SSC-447186] IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] [Complex:R-SSC-8950186] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] [Complex:R-SSC-8950052] IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane]
(inferredTo)	[Complex:R-HSA-8950046] IL12RB1:TYK2 [plasma membrane]