IL12RB1:TYK2 [plasma membrane]

Stable Identifier
R-HSA-8950046
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-12 receptors subunit beta 1: Tyrosin kinase 2
Locations in the PathwayBrowser
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General

The intracellular domain of human Interleukin-12 receptor subunit beta-1 (IL12RB1) but not the intracellular domain of Interleukin-12 receptor subunit beta-2 (IL12RB2) interacts directly with Non-receptor tyrosine-protein kinase (TYK2) (Zou et al. 1997)
Inferred from mouse:
TYK2 associates with IL12RB1. In the absence of TYK2, IL12RB1 can associate with Tyrosine-protein kinase JAK1 (JAK1) (Floss et al. 2016).

Literature References
PubMed ID Title Journal Year
27193299 Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases

Floss, DM, Klöcker, T, Schröder, J, Lamertz, L, Mrotzek, S, Strobl, B, Hermanns, H, Scheller, J

Mol. Biol. Cell 2016
Participants
components
Participant Of
input
hasComponent
output
Inferred From
Il12rb1:Tyk2 [plasma membrane] (Mus musculus)
Inferred To
IL12RB1:TYK2 [plasma membrane] (Bos taurus)
IL12RB1:TYK2 [plasma membrane] (Canis familiaris)
IL12RB1:TYK2 [plasma membrane] (Danio rerio)
IL12RB1:TYK2 [plasma membrane] (Mus musculus)
IL12RB1:TYK2 [plasma membrane] (Rattus norvegicus)
IL12RB1:TYK2 [plasma membrane] (Sus scrofa)
IL12RB1:TYK2 [plasma membrane] (Xenopus tropicalis)
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