Reactome | PTK6 phosphorylates CDKN1B

Schema > Reaction > Entries

PTK6 phosphorylates CDKN1B Show undefined attributes

authored	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
catalystActivity	[CatalystActivity:8848440] protein tyrosine kinase activity of p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol]
catalystActivityReference	[CatalystActivityReference:9643656] protein tyrosine kinase activity of p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8848437] Orlic-Milacic, Marija, 2015-12-08
dbId	8848436
displayName	PTK6 phosphorylates CDKN1B
edited	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
eventOf	[Pathway:R-HSA-8849470] PTK6 Regulates Cell Cycle - Homo sapiens [Pathway:R-HSA-187577] SCF(Skp2)-mediated degradation of p27/p21 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8848415] p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8848424] Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PTK6 phosphorylates CDKN1B BRK phosphorylates p27KIP1
orthologousEvent	[Reaction:R-CEL-8848436] PTK6 phosphorylates CDKN1B - Caenorhabditis elegans [Reaction:R-XTR-8848436] PTK6 phosphorylates CDKN1B - Xenopus tropicalis [Reaction:R-DRE-8848436] PTK6 phosphorylates CDKN1B - Danio rerio [Reaction:R-SSC-8848436] PTK6 phosphorylates CDKN1B - Sus scrofa [Reaction:R-BTA-8848436] PTK6 phosphorylates CDKN1B - Bos taurus [Reaction:R-RNO-8848436] PTK6 phosphorylates CDKN1B - Rattus norvegicus [Reaction:R-MMU-8848436] PTK6 phosphorylates CDKN1B - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-8848007] p-Y342-PTK6 [cytosol] [Complex:R-HSA-8848441] p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol]
precedingEvent	[Reaction:R-HSA-8848414] Activated PTK6 binds CDKN1B - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8848436
summation	[Summation:8848445] PTK6 (BRK) phosphorylates CDKN1B (p27KIP1) bound to the comp...

Referrals

(hasEvent)	[Pathway:R-HSA-8849470] PTK6 Regulates Cell Cycle [Pathway:R-HSA-187577] SCF(Skp2)-mediated degradation of p27/p21
(precedingEvent)	[NegativePrecedingEvent:9763995] Futile Cycle: PTK6 phosphorylates CDKN1B [BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus [NegativePrecedingEvent:9764001] Futile Cycle: PTK6 phosphorylates CDKN1B