Reactome | Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus

Schema > BlackBoxEvent > Entries

Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus Show undefined attributes

category	omitted
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10634350
displayName	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
eventOf	[Pathway:R-DRE-69231] Cyclin D associated events in G1 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Homo sapiens
input	[CandidateSet:R-DRE-8949872] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
output	[CandidateSet:R-DRE-8949874] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
precedingEvent	[Reaction:R-DRE-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Danio rerio [Reaction:R-DRE-8941895] Formation of CDK4/6:CCND complexes - Danio rerio [Reaction:R-DRE-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Danio rerio [Reaction:R-DRE-8848436] PTK6 phosphorylates CDKN1B - Danio rerio
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68323] Danio rerio
stId	R-DRE-8942803
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-69231] Cyclin D associated events in G1
(inferredTo)	[BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus

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