Reactome | Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes

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Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes Show undefined attributes

authored	[InstanceEdit:8942612] Orlic-Milacic, Marija, 2016-10-18
catalystActivity	[CatalystActivity:8942602] protein tyrosine kinase activity of (p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8942612] Orlic-Milacic, Marija, 2016-10-18
dbId	8942607
displayName	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
edited	[InstanceEdit:8949902] Orlic-Milacic, Marija, 2016-11-30
eventOf	[Pathway:R-HSA-69231] Cyclin D associated events in G1 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8848452] Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases [LiteratureReference:8848424] Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4 [LiteratureReference:8942647] p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells [LiteratureReference:8942632] Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma [LiteratureReference:8942636] Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein [LiteratureReference:8848459] p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes [LiteratureReference:8942651] Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity [LiteratureReference:8942689] Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4 [LiteratureReference:8942769] Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control [LiteratureReference:8942792] p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 [LiteratureReference:8942801] Switching cyclin D-Cdk4 kinase activity on and off [LiteratureReference:8942879] Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase [LiteratureReference:8949844] Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4 [LiteratureReference:182497] Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors" [LiteratureReference:8949846] The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis [LiteratureReference:8949850] Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
negativePrecedingEvent	[NegativePrecedingEvent:9763995] Futile Cycle: PTK6 phosphorylates CDKN1B
orthologousEvent	[Reaction:R-DME-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Drosophila melanogaster [Reaction:R-GGA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Gallus gallus [Reaction:R-XTR-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Xenopus tropicalis [Reaction:R-DRE-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Danio rerio [Reaction:R-SSC-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Sus scrofa [Reaction:R-BTA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Bos taurus [Reaction:R-CFA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Canis familiaris [Reaction:R-RNO-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Rattus norvegicus [Reaction:R-MMU-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8942622] CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C) [cytosol]
precedingEvent	[Reaction:R-HSA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8949903] Roger, Pierre P, 2016-11-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8942607
summation	[Summation:8942621] Phosphorylation of Cip/Kip cyclin-dependent kinase (CDK) inh...

Referrals

(hasEvent)	[Pathway:R-HSA-69231] Cyclin D associated events in G1
(precedingEvent)	[BlackBoxEvent:R-HSA-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus

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