The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates ...

created [InstanceEdit:8939716] Orlic-Milacic, Marija, 2016-09-21
dbId 8939715
displayName The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates ...
modified [InstanceEdit:9015289] Orlic-Milacic, Marija, 2017-08-09
schemaClass Summation
text The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates RUNX2 on unknown lysine residues, targeting it for proteasome-mediated degradation. SKP2-triggered RUNX2 degradation negatively regulates osteogenesis by inhibiting differentiation of osteoblasts (Thacker et al. 2016). This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015).
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