SCF(SKP2) polyubiquitinates RUNX2

Stable Identifier
R-HSA-8939706
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates RUNX2 on unknown lysine residues, targeting it for proteasome-mediated degradation. SKP2-triggered RUNX2 degradation negatively regulates osteogenesis by inhibiting differentiation of osteoblasts (Thacker et al. 2016). This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015).

Literature References
PubMed ID Title Journal Year
26778333 Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2

Thacker, G, Kumar, Y, Khan, MP, Shukla, N, Kapoor, I, Kanaujiya, JK, Lochab, S, Ahmed, S, Sanyal, S, Chattopadhyay, N, Trivedi, AK

Biochim. Biophys. Acta 2016
26091038 Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

Wei, J, Shimazu, J, Makinistoglu, MP, Maurizi, A, Kajimura, D, Zong, H, Takarada, T, Lezaki, T, Pessin, JE, Hinoi, E, Karsenty, G

Cell 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RUNX2:SCF(SKP2) [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created