Reactome | SCF(SKP2) polyubiquitinates RUNX2

SCF(SKP2) polyubiquitinates RUNX2

Stable Identifier

R-HSA-8939706

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The SCF(SKP2) E3 ubiquitin ligase complex polyubiquitinates RUNX2 on unknown lysine residues, targeting it for proteasome-mediated degradation. SKP2-triggered RUNX2 degradation negatively regulates osteogenesis by inhibiting differentiation of osteoblasts (Thacker et al. 2016). This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26091038	Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation Wei, J, Shimazu, J, Makinistoglu, MP, Maurizi, A, Kajimura, D, Zong, H, Takarada, T, Lezaki, T, Pessin, JE, Hinoi, E, Karsenty, G	Cell	2015
26778333	Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2 Thacker, G, Kumar, Y, Khan, MP, Shukla, N, Kapoor, I, Kanaujiya, JK, Lochab, S, Ahmed, S, Sanyal, S, Chattopadhyay, N, Trivedi, AK	Biochim. Biophys. Acta	2016