Kynurenine-oxoglutarate transaminase 1 (KYAT1, also known as...

created [InstanceEdit:893590] D'Eustachio, P, 2010-07-01
dbId 893581
displayName Kynurenine-oxoglutarate transaminase 1 (KYAT1, also known as...
modified [InstanceEdit:9939357] D'Eustachio, Peter, 2025-02-25
schemaClass Summation
text Kynurenine-oxoglutarate transaminase 1 (KYAT1, also known as CCBL) catalyzes the reaction of kynurenine (L-KYN) and 2-oxoglutarate (2OG) to form kynurenate (KYNA), L-glutamate, and water, in a two-step reaction involving an unstable intermediate, 4-(2-aminophenyl)-2,4-dioxobutanoate. The active form of KYAT1 is a homodimer with one molecule of pyridoxal phosphate (PXLP) bound to each monomer (Baran et al. 1994, Han et al. 2009, Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).

The alpha keto acids indole-3-propionic acid (I3PROPA) and indole-3-lactic acid (I3LACT) are potent inhibitors of KYAT1 (Han et al. 2009). Phenylalanine is an effective competitive inhibitor of kynurenine aminotransferase 1 (Han et al. 2004).

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