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RUNX3:NOTCH1 Coactivator Complex
Stable Identifier
R-HSA-8878230
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates NOTCH signaling (Homo sapiens)
HES1 gene transcription is inhibited by RUNX3 (Homo sapiens)
RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm] (Homo sapiens)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
RUNX3 binds the NOTCH1 coactivator complex (Homo sapiens)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter (Homo sapiens)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm] (Homo sapiens)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19800882
RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
Exp. Cell Res.
2010
Participants
components
NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
RUNX3 [nucleoplasm] (Homo sapiens)
Participant Of
input
RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
output
RUNX3 binds the NOTCH1 coactivator complex
hasComponent
RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]
Inferred To
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Bos taurus)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Canis familiaris)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Danio rerio)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Drosophila melanogaster)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Gallus gallus)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Mus musculus)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Rattus norvegicus)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Sus scrofa)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Taeniopygia guttata)
RUNX3:NOTCH1 Coactivator Complex [nucleoplasm] (Xenopus tropicalis)
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