Reactome | RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8878238] Orlic-Milacic, Marija, 2016-06-30
dbId	8878239
displayName	RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-2197548] HES1 gene [nucleoplasm] [Complex:R-HSA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:8878223] RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
maxDepth	5
modified	[InstanceEdit:8959866] Orlic-Milacic, Marija, 2017-01-31
name	RUNX3:NOTCH1 coactivator complex:HES1 gene
negativelyRegulates	[NegativeGeneExpressionRegulation:R-HSA-8878245] Negative gene expression regulation by 'RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-8878237] RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8878239

(output)	[Reaction:R-HSA-8878237] RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
(regulator)	[NegativeGeneExpressionRegulation:R-HSA-8878245] Negative gene expression regulation by 'RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]'

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