Reactome | RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter

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RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter Show undefined attributes

authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8878238] Orlic-Milacic, Marija, 2016-06-30
dbId	8878237
displayName	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf	[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8878243] HES1 gene transcription is inhibited by RUNX3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2197548] HES1 gene [nucleoplasm] [Complex:R-HSA-8878230] RUNX3:NOTCH1 Coactivator Complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8878223] RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
output	[Complex:R-HSA-8878239] RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8878220] RUNX3 binds the NOTCH1 coactivator complex - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8878237
summation	[Summation:8941851] RUNX3, associated with the NOTCH1 coactivator complex, binds...

Referrals

(hasEvent)	[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-8878243] HES1 gene transcription is inhibited by RUNX3

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