Reactome | p-ULK1 phosphorylates DENND3

Schema > Reaction > Entries

p-ULK1 phosphorylates DENND3 Show undefined attributes

catalystActivity	[CatalystActivity:10424129] protein serine/threonine kinase activity of p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10424131
displayName	p-ULK1 phosphorylates DENND3
eventOf	[Pathway:R-BTA-8876198] RAB GEFs exchange GTP for GDP on RABs - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8876454] DENND3 exchanges GTP for GDP on RAB12 - Bos taurus
inferredFrom	[Reaction:R-HSA-8876446] p-ULK1 phosphorylates DENND3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-BTA-8876435] DENND3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-ULK1 phosphorylates DENND3
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-BTA-8876434] phospho-DENND3 [cytosol]
precedingEvent	[BlackBoxEvent:R-BTA-5672008] Thr-180 of ULK1 is phosphorylated - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8876446
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8876198] RAB GEFs exchange GTP for GDP on RABs
(precedingEvent)	[Reaction:R-BTA-8876454] DENND3 exchanges GTP for GDP on RAB12
(inferredTo)	[Reaction:R-HSA-8876446] p-ULK1 phosphorylates DENND3

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