Reactome | RAPGEF1 binds CRK,CRKL

Schema > Reaction > Entries

RAPGEF1 binds CRK,CRKL Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8875560] Orlic-Milacic, Marija, 2016-06-07
dbId	8875558
displayName	RAPGEF1 binds CRK,CRKL
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1 - Homo sapiens
followingEvent	[Reaction:R-HSA-8875568] RAPGEF1 activates RAP1 - Homo sapiens
input	[Complex:R-HSA-8875548] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] [EntityWithAccessionedSequence:R-HSA-913472] RAPGEF1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8875541] Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL [LiteratureReference:8875559] Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RAPGEF1 binds CRK,CRKL
orthologousEvent	[Reaction:R-GGA-8875558] RAPGEF1 binds CRK,CRKL - Gallus gallus [Reaction:R-XTR-8875558] RAPGEF1 binds CRK,CRKL - Xenopus tropicalis [Reaction:R-SSC-8875558] RAPGEF1 binds CRK,CRKL - Sus scrofa [Reaction:R-BTA-8875558] RAPGEF1 binds CRK,CRKL - Bos taurus [Reaction:R-CFA-8875558] RAPGEF1 binds CRK,CRKL - Canis familiaris [Reaction:R-RNO-8875558] RAPGEF1 binds CRK,CRKL - Rattus norvegicus [Reaction:R-MMU-8875558] RAPGEF1 binds CRK,CRKL - Mus musculus
output	[Complex:R-HSA-8875561] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8875540] GAB1 recruits CRK,CRKL to MET - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8875558
summation	[Summation:8875563] Once recruited to the activated MET receptor complex by bind...

Referrals

(precedingEvent)	[Reaction:R-HSA-8875568] RAPGEF1 activates RAP1
(hasEvent)	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1