RAPGEF1 binds CRK,CRKL

Stable Identifier
R-HSA-8875558
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once recruited to the activated MET receptor complex by binding to tyrosine phosphorylated GAB1, CRK or related CRKL bind the Rap guanine nucleotide exchange factor RAPGEF1 (C3G) (Sakkab et al. 2000, Lamorte et al. 2002).

Literature References
PubMed ID Title Journal Year
12006644 Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

Lamorte, L, Royal, I, Naujokas, M, Park, M

Mol. Biol. Cell 2002
10753869 Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

Sakkab, D, Lewitzky, M, Posern, G, Schaeper, U, Sachs, M, Birchmeier, W, Feller, SM

J. Biol. Chem. 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created