Reactome | RAPGEF1 binds CRK,CRKL

RAPGEF1 binds CRK,CRKL

Stable Identifier

R-HSA-8875558

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Once recruited to the activated MET receptor complex by binding to tyrosine phosphorylated GAB1, CRK or related CRKL bind the Rap guanine nucleotide exchange factor RAPGEF1 (C3G) (Sakkab et al. 2000, Lamorte et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
10753869	Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL Sakkab, D, Lewitzky, M, Posern, G, Schaeper, U, Sachs, M, Birchmeier, W, Feller, SM	J. Biol. Chem.	2000
12006644	Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions Lamorte, L, Royal, I, Naujokas, M, Park, M	Mol. Biol. Cell	2002