Reactome | RAPGEF1 [cytosol]

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RAPGEF1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9024740] p-CRKL:RAPGEF1 [cytosol] - Homo sapiens [Complex:R-HSA-9024734] CRKL:RAPGEF1 [cytosol] - Homo sapiens [Complex:R-HSA-381957] PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8875558] RAPGEF1 binds CRK,CRKL - Homo sapiens [Reaction:R-HSA-912734] CBL:CRKL binds RAPGEF1 - Homo sapiens [Reaction:R-HSA-170978] p-FRS2:CRKL binds C3G - Homo sapiens [Reaction:R-HSA-382052] p130Cas and C3G bind PDGFR bound Crk - Homo sapiens
created	[InstanceEdit:913471] Jupe, S, 2010-07-14
dbId	913472
displayName	RAPGEF1 [cytosol]
endCoordinate	1077
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-913472] Rapgef1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-913472] Rapgef1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-913472] RAPGEF1 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-913472] RAPGEF1 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-913472] RAPGEF1 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-913472] rapgef5 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-913472] rapgef1 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-913472] RAPGEF1 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-913472] C3G [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-913472] RAPGEF1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-913472] gefP [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-913472] efc25 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-913472] CDC25 [cytosol] - Saccharomyces cerevisiae
modified	[InstanceEdit:8875562] Orlic-Milacic, Marija, 2016-06-07
name	RAPGEF1 Rap guanine nucleotide exchange factor 1 RPGF1_HUMAN C3G
referenceEntity	[ReferenceGeneProduct:405669] UniProt:Q13905 RAPGEF1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-913472
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-HSA-9024734] CRKL:RAPGEF1 [cytosol] [Complex:R-HSA-9024740] p-CRKL:RAPGEF1 [cytosol] [Complex:R-HSA-914209] p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] [Complex:R-HSA-381957] PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] [Complex:R-HSA-8875561] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] [Complex:R-HSA-190070] Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane]
(hasCandidate)	[CandidateSet:R-HSA-9020391] RAC3 effectors [cytosol]
(input)	[Reaction:R-HSA-912734] CBL:CRKL binds RAPGEF1 [Reaction:R-HSA-382052] p130Cas and C3G bind PDGFR bound Crk [Reaction:R-HSA-8875558] RAPGEF1 binds CRK,CRKL [Reaction:R-HSA-170978] p-FRS2:CRKL binds C3G
(activeUnit)	[CatalystActivity:8875567] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]

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