Reactome | GAB1 recruits CRK,CRKL to MET

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GAB1 recruits CRK,CRKL to MET Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8875539] Orlic-Milacic, Marija, 2016-06-07
dbId	8875540
displayName	GAB1 recruits CRK,CRKL to MET
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8875661] GGA3 associates with activated MET receptor - Homo sapiens [Reaction:R-HSA-8875558] RAPGEF1 binds CRK,CRKL - Homo sapiens [BlackBoxEvent:R-HSA-8875576] CRK,CRKL recruits RAC1 GEF to activated MET - Homo sapiens
input	[DefinedSet:R-HSA-381945] CRK, CRKL [cytosol] [DefinedSet:R-HSA-8851943] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8875541] Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL [LiteratureReference:8875550] Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program [LiteratureReference:8875549] A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein [LiteratureReference:8875547] Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation [LiteratureReference:8851912] Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GAB1 recruits CRK,CRKL to MET
orthologousEvent	[Reaction:R-GGA-8875540] GAB1 recruits CRK,CRKL to MET - Gallus gallus [Reaction:R-XTR-8875540] GAB1 recruits CRK,CRKL to MET - Xenopus tropicalis [Reaction:R-DRE-8875540] GAB1 recruits CRK,CRKL to MET - Danio rerio [Reaction:R-SSC-8875540] GAB1 recruits CRK,CRKL to MET - Sus scrofa [Reaction:R-BTA-8875540] GAB1 recruits CRK,CRKL to MET - Bos taurus [Reaction:R-CFA-8875540] GAB1 recruits CRK,CRKL to MET - Canis familiaris [Reaction:R-RNO-8875540] GAB1 recruits CRK,CRKL to MET - Rattus norvegicus [Reaction:R-MMU-8875540] GAB1 recruits CRK,CRKL to MET - Mus musculus
output	[Complex:R-HSA-8875548] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane]
precedingEvent	[Reaction:R-HSA-8851933] MET phosphorylates GAB1 - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8875540
summation	[Summation:8875554] Splicing isoforms of adapter protein CRK, CRK-1 (CRKI) and C...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-8875661] GGA3 associates with activated MET receptor [Reaction:R-HSA-8875558] RAPGEF1 binds CRK,CRKL [BlackBoxEvent:R-HSA-8875576] CRK,CRKL recruits RAC1 GEF to activated MET
(hasEvent)	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1

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