Reactome | RAPGEF1 activates RAP1

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RAPGEF1 activates RAP1 Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity	[CatalystActivity:8875567] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8875566] Orlic-Milacic, Marija, 2016-06-07
dbId	8875568
displayName	RAPGEF1 activates RAP1
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-354074] RAP1:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8875541] Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL [LiteratureReference:8875559] Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RAPGEF1 activates RAP1
orthologousEvent	[Reaction:R-GGA-8875568] RAPGEF1 activates RAP1 - Gallus gallus [Reaction:R-XTR-8875568] RAPGEF1 activates RAP1 - Xenopus tropicalis [Reaction:R-SSC-8875568] RAPGEF1 activates RAP1 - Sus scrofa [Reaction:R-BTA-8875568] RAPGEF1 activates RAP1 - Bos taurus [Reaction:R-CFA-8875568] RAPGEF1 activates RAP1 - Canis familiaris [Reaction:R-RNO-8875568] RAPGEF1 activates RAP1 - Rattus norvegicus [Reaction:R-MMU-8875568] RAPGEF1 activates RAP1 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-354126] RAP1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-8875558] RAPGEF1 binds CRK,CRKL - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8875568
summation	[Summation:8875571] The level of activated (GTP-bound) RAP1 increases rapidly af...

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[Pathway:R-HSA-8875555] MET activates RAP1 and RAC1