Reactome | NMRK1 phosphorylates NAR to yield NAMN

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NMRK1 phosphorylates NAR to yield NAMN Show undefined attributes

catalystActivity	[CatalystActivity:11102258] nicotinate riboside kinase activity of NMRK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11102260
displayName	NMRK1 phosphorylates NAR to yield NAMN
eventOf	[Pathway:R-SCE-196807] Nicotinate metabolism - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Saccharomyces cerevisiae [Reaction:R-SCE-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - Saccharomyces cerevisiae [Reaction:R-SCE-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-8869365] NAR [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NMRK1 phosphorylates NAR to yield NAMN beta-D-ribosylnicotinate + ATP => nicotinate beta-D-ribonucleotide + ADP + H(+) NAR + ATP(4-) => NAMN + ADP(3-) + H+
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-8869359] NAMN [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-8869606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-SCE-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD [Reaction:R-SCE-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD [Reaction:R-SCE-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
(inferredTo)	[Reaction:R-HSA-8869606] NMRK1 phosphorylates NAR to yield NAMN

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