Reactome | Synthesis of active ubiquitin: roles of E1 and E2 enzymes

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Synthesis of active ubiquitin: roles of E1 and E2 enzymes Show undefined attributes

authored	[InstanceEdit:8866655] May, Bruce, 2016-04-02
created	[InstanceEdit:8866651] May, Bruce, 2016-04-02
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	8866652
displayName	Synthesis of active ubiquitin: roles of E1 and E2 enzymes
doi	10.3180/R-HSA-8866652.1
edited	[InstanceEdit:8866655] May, Bruce, 2016-04-02
eventOf	[Pathway:R-HSA-8852135] Protein ubiquitination - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18276] protein ubiquitination
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8853529] OTULIN,USP5 cleaves UBB yielding ubiquitin - Homo sapiens [Reaction:R-HSA-8853515] OTULIN,USP5 cleaves UBC yielding ubiquitin - Homo sapiens [Reaction:R-HSA-8853514] UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin - Homo sapiens [Reaction:R-HSA-8853503] UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin - Homo sapiens [Reaction:R-HSA-8852134] UBA1 adenylates ubiquitin in the cytosol - Homo sapiens [Reaction:R-HSA-8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol - Homo sapiens [Reaction:R-HSA-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol - Homo sapiens [Reaction:R-HSA-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Homo sapiens [Reaction:R-HSA-8865090] UBA6 adenylates ubiquitin in the cytosol - Homo sapiens [Reaction:R-HSA-8865098] UBA6 conjugates ubiquitin to UBA6 in the cytosol - Homo sapiens [Reaction:R-HSA-8865050] Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol - Homo sapiens [Reaction:R-HSA-8852127] UBA6 conjugates ubiquitin to cytosolic E2 enzymes - Homo sapiens [Reaction:R-HSA-8852128] UBA1 adenylates ubiquitin in the nucleoplasm - Homo sapiens [Reaction:R-HSA-8852136] UBA1 conjugates ubiquitin to UBA1 in the nucleus - Homo sapiens [Reaction:R-HSA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Homo sapiens [Reaction:R-HSA-8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:8853528] The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors [LiteratureReference:8852041] Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging [LiteratureReference:8865067] Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation [LiteratureReference:8865039] Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown [LiteratureReference:982966] The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins [LiteratureReference:8869303] Perilous journey: a tour of the ubiquitin-proteasome system [LiteratureReference:8869305] E2 enzymes: more than just middle men
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Synthesis of active ubiquitin: roles of E1 and E2 enzymes
orthologousEvent	[Pathway:R-PFA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Plasmodium falciparum [Pathway:R-DDI-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Dictyostelium discoideum [Pathway:R-CEL-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Caenorhabditis elegans [Pathway:R-DME-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Drosophila melanogaster [Pathway:R-GGA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Gallus gallus [Pathway:R-XTR-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Xenopus tropicalis [Pathway:R-DRE-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Danio rerio [Pathway:R-SSC-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Sus scrofa [Pathway:R-BTA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Bos taurus [Pathway:R-CFA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Canis familiaris [Pathway:R-RNO-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Rattus norvegicus [Pathway:R-MMU-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Mus musculus
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934570] Azevedo, Jorge E, 2016-08-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8866652
summation	[Summation:8866650] Ubiquitin monomers are processed from larger precursors and ...
updateTrackers	[UpdateTracker:9782614] Update Tracker - [Pathway:8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - v59:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782614] Update Tracker - [Pathway:8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - v59:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-8852135] Protein ubiquitination

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