Reactome | Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol

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Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol Show undefined attributes

authored	[InstanceEdit:8852137] May, Bruce, 2016-01-11
catalystActivity	[CatalystActivity:8865193] ubiquitin activating enzyme activity of Ub-Cys625-UBA6 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8865073] May, Bruce, 2016-03-20
dbId	8865050
displayName	Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol
edited	[InstanceEdit:8852137] May, Bruce, 2016-01-11
eventOf	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Homo sapiens
followingEvent	[Reaction:R-HSA-8852127] UBA6 conjugates ubiquitin to cytosolic E2 enzymes - Homo sapiens
inferredFrom	[Reaction:R-HSA-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol] [Complex:R-HSA-8852066] Ub-Cys625-UBA6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8852041] Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging [LiteratureReference:8865074] UBE1L2, a novel E1 enzyme specific for ubiquitin [LiteratureReference:8934565] Activating the ubiquitin family: UBA6 challenges the field
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-HSA-8852097] Ub-Cys625-UBA6:ubiquitin adenylate [cytosol]
precedingEvent	[Reaction:R-HSA-8865098] UBA6 conjugates ubiquitin to UBA6 in the cytosol - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934570] Azevedo, Jorge E, 2016-08-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8865050
summation	[Summation:8865095] As inferred from the homologous UBA1, activation of ubiquiti...

Referrals

(hasEvent)	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes
(precedingEvent)	[Reaction:R-HSA-8852127] UBA6 conjugates ubiquitin to cytosolic E2 enzymes
(inferredTo)	[Reaction:R-HSA-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol

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