Reactome | UBA1 adenylates ubiquitin in the cytosol

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UBA1 adenylates ubiquitin in the cytosol Show undefined attributes

authored	[InstanceEdit:8852137] May, Bruce, 2016-01-11
catalystActivity	[CatalystActivity:8865063] ubiquitin activating enzyme activity of UBA1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8852138] May, Bruce, 2016-01-13
dbId	8852134
displayName	UBA1 adenylates ubiquitin in the cytosol
edited	[InstanceEdit:8852137] May, Bruce, 2016-01-11
eventOf	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Homo sapiens
followingEvent	[Reaction:R-HSA-8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol] [EntityWithAccessionedSequence:R-HSA-947698] UBA1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8852041] Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging [LiteratureReference:8865067] Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation [LiteratureReference:8865039] Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown [LiteratureReference:8934565] Activating the ubiquitin family: UBA6 challenges the field
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	UBA1 adenylates ubiquitin in the cytosol
orthologousEvent	[Reaction:R-HSA-8865090] UBA6 adenylates ubiquitin in the cytosol - Homo sapiens [Reaction:R-PFA-8852134] UBA1 adenylates ubiquitin in the cytosol - Plasmodium falciparum [Reaction:R-DDI-8852134] UBA1 adenylates ubiquitin in the cytosol - Dictyostelium discoideum [Reaction:R-CEL-8852134] UBA1 adenylates ubiquitin in the cytosol - Caenorhabditis elegans [Reaction:R-DME-8852134] UBA1 adenylates ubiquitin in the cytosol - Drosophila melanogaster [Reaction:R-GGA-8852134] UBA1 adenylates ubiquitin in the cytosol - Gallus gallus [Reaction:R-XTR-8852134] UBA1 adenylates ubiquitin in the cytosol - Xenopus tropicalis [Reaction:R-DRE-8852134] UBA1 adenylates ubiquitin in the cytosol - Danio rerio [Reaction:R-SSC-8852134] UBA1 adenylates ubiquitin in the cytosol - Sus scrofa [Reaction:R-BTA-8852134] UBA1 adenylates ubiquitin in the cytosol - Bos taurus [Reaction:R-CFA-8852134] UBA1 adenylates ubiquitin in the cytosol - Canis familiaris [Reaction:R-RNO-8852134] UBA1 adenylates ubiquitin in the cytosol - Rattus norvegicus [Reaction:R-MMU-8852134] UBA1 adenylates ubiquitin in the cytosol - Mus musculus
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-HSA-8852068] UBA1:ubiquitin adenylate [cytosol]
precedingEvent	[Reaction:R-HSA-8853529] OTULIN,USP5 cleaves UBB yielding ubiquitin - Homo sapiens [Reaction:R-HSA-8853515] OTULIN,USP5 cleaves UBC yielding ubiquitin - Homo sapiens [Reaction:R-HSA-8853503] UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin - Homo sapiens [Reaction:R-HSA-8853514] UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934570] Azevedo, Jorge E, 2016-08-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8852134
summation	[Summation:8865057] Activation of ubiquitin by UBA1 proceeds through 3 steps: ad...

Referrals

(precedingEvent)	[Reaction:R-HSA-8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol
(hasEvent)	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes

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