Reactome | UBA1 conjugates ubiquitin to cytosolic E2 enzymes

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UBA1 conjugates ubiquitin to cytosolic E2 enzymes Show undefined attributes

authored	[InstanceEdit:8852137] May, Bruce, 2016-01-11
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8852138] May, Bruce, 2016-01-13
dbId	8852129
displayName	UBA1 conjugates ubiquitin to cytosolic E2 enzymes
edited	[InstanceEdit:8852137] May, Bruce, 2016-01-11
eventOf	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Homo sapiens
input	[DefinedSet:R-HSA-8852103] E2 ubiquitin conjugating enzyme (UBA1 substrate) [cytosol] [Complex:R-HSA-8852079] Ub-Cys632-UBA1:ubiquitin adenylate [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8852041] Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging [LiteratureReference:8852247] E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer [LiteratureReference:8865039] Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	UBA1 conjugates ubiquitin to cytosolic E2 enzymes
orthologousEvent	[Reaction:R-PFA-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Plasmodium falciparum [Reaction:R-DDI-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Dictyostelium discoideum [Reaction:R-CEL-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Caenorhabditis elegans [Reaction:R-DME-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Drosophila melanogaster [Reaction:R-GGA-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Gallus gallus [Reaction:R-XTR-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Xenopus tropicalis [Reaction:R-DRE-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Danio rerio [Reaction:R-SSC-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Sus scrofa [Reaction:R-BTA-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Bos taurus [Reaction:R-CFA-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Canis familiaris [Reaction:R-RNO-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Rattus norvegicus [Reaction:R-MMU-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Mus musculus
output	[Complex:R-HSA-8852251] Ub:E2 (UBA1 substrate) [cytosol] [Complex:R-HSA-8852068] UBA1:ubiquitin adenylate [cytosol]
precedingEvent	[Reaction:R-HSA-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934570] Azevedo, Jorge E, 2016-08-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8852129
summation	[Summation:8865040] In the cytosol, the UBA1-ubiquitin thiol ester conjugate tra...

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[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes