Reactome | Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus

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Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus Show undefined attributes

authored	[InstanceEdit:8852137] May, Bruce, 2016-01-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8852138] May, Bruce, 2016-01-13
dbId	8852131
displayName	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus
edited	[InstanceEdit:8852137] May, Bruce, 2016-01-11
eventOf	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Homo sapiens
followingEvent	[Reaction:R-HSA-8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [DefinedSet:R-HSA-68524] Ub [nucleoplasm] [Complex:R-HSA-8852095] Ub-Cys632-UBA1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8852041] Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging [LiteratureReference:8865061] Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent [LiteratureReference:8865039] Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown [LiteratureReference:8865067] Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation [LiteratureReference:8934565] Activating the ubiquitin family: UBA6 challenges the field
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus
orthologousEvent	[Reaction:R-PFA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Plasmodium falciparum [Reaction:R-SCE-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Saccharomyces cerevisiae [Reaction:R-SPO-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Schizosaccharomyces pombe [Reaction:R-DDI-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Dictyostelium discoideum [Reaction:R-CEL-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Caenorhabditis elegans [Reaction:R-DME-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Drosophila melanogaster [Reaction:R-GGA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Gallus gallus [Reaction:R-XTR-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Xenopus tropicalis [Reaction:R-DRE-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Danio rerio [Reaction:R-SSC-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Sus scrofa [Reaction:R-BTA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Bos taurus [Reaction:R-CFA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Canis familiaris [Reaction:R-RNO-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Rattus norvegicus [Reaction:R-MMU-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Mus musculus
output	[SimpleEntity:R-ALL-113541] PPi [nucleoplasm] [Complex:R-HSA-8852059] Ub-Cys632-UBA1:ubiquitin adenylate [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8852136] UBA1 conjugates ubiquitin to UBA1 in the nucleus - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934570] Azevedo, Jorge E, 2016-08-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8852131
summation	[Summation:8865043] UBA1 is located in both the cytoplasm and nucleus (Grenfell ...

Referrals

(precedingEvent)	[Reaction:R-HSA-8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes
(hasEvent)	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes

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