Reactome | Synthesis of active ubiquitin: roles of E1 and E2 enzymes

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Synthesis of active ubiquitin: roles of E1 and E2 enzymes Show undefined attributes

created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11129162
displayName	Synthesis of active ubiquitin: roles of E1 and E2 enzymes
eventOf	[Pathway:R-PFA-8852135] Protein ubiquitination - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:18276] protein ubiquitination
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-PFA-8853514] UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin - Plasmodium falciparum [Reaction:R-PFA-8853503] UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin - Plasmodium falciparum [Reaction:R-PFA-8852134] UBA1 adenylates ubiquitin in the cytosol - Plasmodium falciparum [Reaction:R-PFA-8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol - Plasmodium falciparum [Reaction:R-PFA-8852132] Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol - Plasmodium falciparum [Reaction:R-PFA-8852129] UBA1 conjugates ubiquitin to cytosolic E2 enzymes - Plasmodium falciparum [Reaction:R-PFA-8852127] UBA6 conjugates ubiquitin to cytosolic E2 enzymes - Plasmodium falciparum [Reaction:R-PFA-8852128] UBA1 adenylates ubiquitin in the nucleoplasm - Plasmodium falciparum [Reaction:R-PFA-8852136] UBA1 conjugates ubiquitin to UBA1 in the nucleus - Plasmodium falciparum [Reaction:R-PFA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Plasmodium falciparum [Reaction:R-PFA-8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of active ubiquitin: roles of E1 and E2 enzymes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-8866652
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-8852135] Protein ubiquitination
(inferredTo)	[Pathway:R-HSA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes

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