Reactome | Active transport of ubiquitinated CD274 from ER to cytosol

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Active transport of ubiquitinated CD274 from ER to cytosol Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927346] Tiwari, Krishna, 2024-11-05
category	dissociation
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9931260] Tiwari, Krishna, 2024-12-11
dbId	9931264
displayName	Active transport of ubiquitinated CD274 from ER to cytosol
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) - Homo sapiens
followingEvent	[Reaction:R-HSA-9931314] Proteasomal degradation of polyUb-p-S195-CD274 - Homo sapiens
input	[SimpleEntity:R-ALL-8931885] ATP [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [Complex:R-HSA-9931312] Poly-Ub-p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935388] Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active transport of ubiquitinated CD274 from ER to cytosol
orthologousEvent	[Reaction:R-GGA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Gallus gallus [Reaction:R-SSC-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Sus scrofa [Reaction:R-BTA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Bos taurus [Reaction:R-CFA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Canis familiaris [Reaction:R-RNO-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Rattus norvegicus [Reaction:R-MMU-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-8931884] ADP [endoplasmic reticulum lumen] [Complex:R-HSA-8866531] ERAD complex [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-113551] Pi [endoplasmic reticulum lumen] [Complex:R-HSA-9931275] polyUb-p-S195-CD274 [cytosol]
precedingEvent	[Reaction:R-HSA-9931298] Ubiquitination of CD274 by ERAD complex - Homo sapiens
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9931264
summation	[Summation:9937962] The ERAD complex consists of ATPases like VCP responsible fo...

Referrals

(hasEvent)	[Pathway:R-HSA-9931269] AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
(precedingEvent)	[Reaction:R-HSA-9931314] Proteasomal degradation of polyUb-p-S195-CD274