Reactome | ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane]

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ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane
consumedByEvent	[Reaction:R-HSA-8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol - Homo sapiens
created	[InstanceEdit:8866845] Rothfels, Karen, 2016-04-04
crossReference	[DatabaseIdentifier:12020976] Mondo:0009061
dbId	8866846
disease	[Disease:5678942] cystic fibrosis
displayName	ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
hasComponent	[Complex:R-HSA-8866531] ERAD complex [endoplasmic reticulum membrane] [DefinedSet:R-HSA-113595] Ub [cytosol] [EntityWithAccessionedSequence:R-HSA-8866842] ub-CFTR F508del [endoplasmic reticulum membrane]
inDisease	true
includedLocation	[Compartment:70101] cytosol [Compartment:927893] endoplasmic reticulum quality control compartment
isChimeric	false
maxDepth	5
modified	[InstanceEdit:9634795] Rothfels, Karen, 2019-01-15
name	ub-CFTR F508del:ERAD complex
producedByEvent	[Reaction:R-HSA-8866856] RNF5 and RNF185 ubiquitinate CFTR F508del - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8866846
updateTrackers	[UpdateTracker:9897064] Update Tracker - [Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - v61:[updateContainedComponent] [UpdateTracker:9900026] Update Tracker - [Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - v67:[updateContainedComponent] [UpdateTracker:9900092] Update Tracker - [Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - v68:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9897064] Update Tracker - [Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - v61:[updateContainedComponent] [UpdateTracker:9900026] Update Tracker - [Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - v67:[updateContainedComponent] [UpdateTracker:9900092] Update Tracker - [Complex:8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - v68:[add_removeHasComponent]
(output)	[Reaction:R-HSA-8866856] RNF5 and RNF185 ubiquitinate CFTR F508del
(input)	[Reaction:R-HSA-8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol
(diseaseEntity)	[EntityFunctionalStatus:9630134] gain_of_function of ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane]

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