Reactome | ERAD complex [endoplasmic reticulum membrane]

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ERAD complex [endoplasmic reticulum membrane] Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane
componentOf	[Complex:R-MMU-8866538] misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] - Mus musculus [Complex:R-MMU-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation - Mus musculus [Reaction:R-MMU-9931313] p-S195-CD274 binds ERAD complex - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10078092
displayName	ERAD complex [endoplasmic reticulum membrane]
hasComponent	[Complex:R-MMU-8866529] DERL oligomer [endoplasmic reticulum membrane] [Complex:R-MMU-8866522] ERLIN1:ERLIN2 [endoplasmic reticulum membrane] [DefinedSet:R-MMU-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] [DefinedSet:R-MMU-8866527] RNF5,RNF185 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-MMU-1911545] Sel1l [endoplasmic reticulum membrane] [Complex:R-MMU-5362364] VCP hexamer [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8866531] ERAD complex [endoplasmic reticulum membrane] - Homo sapiens
maxDepth	4
name	ERAD complex
producedByEvent	[Reaction:R-MMU-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Mus musculus [Reaction:R-MMU-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-8866531
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-MMU-8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation [Reaction:R-MMU-9931313] p-S195-CD274 binds ERAD complex
(output)	[Reaction:R-MMU-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol [Reaction:R-MMU-9931264] Active transport of ubiquitinated CD274 from ER to cytosol
(hasComponent)	[Complex:R-MMU-8866538] misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] [Complex:R-MMU-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] [Complex:R-MMU-9931263] p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]
(activeUnit)	[CatalystActivity:10096839] ubiquitin protein ligase activity of p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]
(inferredTo)	[Complex:R-HSA-8866531] ERAD complex [endoplasmic reticulum membrane]

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