Reactome | TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937

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TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 Show undefined attributes

authored	[InstanceEdit:6793024] May, Bruce, 2015-08-28
catalystActivity	[CatalystActivity:6793073] rRNA (adenine-N6,N6-)-dimethyltransferase activity of TFB1M [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643244] rRNA (adenine-N6,N6-)-dimethyltransferase activity of TFB1M [mitochondrial matrix] Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6793083] May, Bruce, 2015-08-29
dbId	6793066
displayName	TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937
edited	[InstanceEdit:6793024] May, Bruce, 2015-08-28
eventOf	[Pathway:R-HSA-6793080] rRNA modification in the mitochondrion - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6792974] 12S rRNA [mitochondrial matrix] 4 × [SimpleEntity:R-ALL-2162265] AdoMet [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:163224] A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine [LiteratureReference:163225] Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop [LiteratureReference:6793079] Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation [LiteratureReference:6793300] Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis [LiteratureReference:6793294] Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness [LiteratureReference:5210025] Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness [LiteratureReference:5210047] Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome [LiteratureReference:6807387] Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1 [LiteratureReference:8868768] Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937
output	[EntityWithAccessionedSequence:R-HSA-6793060] 12S rRNA containing 6-dimethylA-936,937 [mitochondrial matrix] 4 × [SimpleEntity:R-ALL-2162252] AdoHcy [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8868767] Bogenhagen, Daniel F, 2016-04-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6793066
summation	[Summation:6798642] TFB1M transfers methyl groups from S-adenosylmethionine to t...

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(hasEvent)

[Pathway:R-HSA-6793080] rRNA modification in the mitochondrion

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