Reactome | COQ3 methylates DeMQ10H2

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COQ3 methylates DeMQ10H2 Show undefined attributes

authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2162293] 3-demethylubiquinol 3-O-methyltransferase activity of COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162189] Williams, MG, 2012-03-15
crossReference	[DatabaseIdentifier:12667900] RHEA:44412 [DatabaseIdentifier:9856132] RHEA:44413
dbId	2162186
displayName	COQ3 methylates DeMQ10H2
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
eventOf	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9856502] mito-STARD7 transports Q10 to outer mitochondrial membrane - Homo sapiens
input	[SimpleEntity:R-ALL-2162265] AdoMet [mitochondrial matrix] [SimpleEntity:R-ALL-2162212] DeMQ10H2 [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2162320] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis [LiteratureReference:9856230] Structural and biochemical studies reveal UbiG/Coq3 as a class of novel membrane-binding proteins [LiteratureReference:9909211] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	COQ3 methylates DeMQ10H2 DeMQ10H2 is methylated to Q10H2 by COQ3
orthologousEvent	[Reaction:R-SCE-2162186] COQ3 methylates DeMQ10H2 - Saccharomyces cerevisiae [Reaction:R-SPO-2162186] COQ3 methylates DeMQ10H2 - Schizosaccharomyces pombe [Reaction:R-DDI-2162186] COQ3 methylates DeMQ10H2 - Dictyostelium discoideum [Reaction:R-CEL-2162186] COQ3 methylates DeMQ10H2 - Caenorhabditis elegans [Reaction:R-DME-2162186] COQ3 methylates DeMQ10H2 - Drosophila melanogaster [Reaction:R-GGA-2162186] COQ3 methylates DeMQ10H2 - Gallus gallus [Reaction:R-XTR-2162186] COQ3 methylates DeMQ10H2 - Xenopus tropicalis [Reaction:R-DRE-2162186] COQ3 methylates DeMQ10H2 - Danio rerio [Reaction:R-SSC-2162186] COQ3 methylates DeMQ10H2 - Sus scrofa [Reaction:R-BTA-2162186] COQ3 methylates DeMQ10H2 - Bos taurus [Reaction:R-CFA-2162186] COQ3 methylates DeMQ10H2 - Canis familiaris [Reaction:R-RNO-2162186] COQ3 methylates DeMQ10H2 - Rattus norvegicus [Reaction:R-MMU-2162186] COQ3 methylates DeMQ10H2 - Mus musculus
output	[SimpleEntity:R-ALL-2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:R-ALL-2162198] CoQH2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 - Homo sapiens [Reaction:R-HSA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2162186
summation	[Summation:2167903] Mitochondrial COQ3 is an O-methyltransferase required in the...
updateTrackers	[UpdateTracker:9864082] Update Tracker - [Reaction:2162186] COQ3 methylates DeMQ10H2 - v88:[addLiteratureReference] [UpdateTracker:9910963] Update Tracker - [Reaction:2162186] COQ3 methylates DeMQ10H2 - v89:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864082] Update Tracker - [Reaction:2162186] COQ3 methylates DeMQ10H2 - v88:[addLiteratureReference] [UpdateTracker:9910963] Update Tracker - [Reaction:2162186] COQ3 methylates DeMQ10H2 - v89:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis
(precedingEvent)	[Reaction:R-HSA-9856502] mito-STARD7 transports Q10 to outer mitochondrial membrane

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