Reactome | SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy

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SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy Show undefined attributes

catalystActivity	[CatalystActivity:11101880] S-adenosyl-L-methionine transmembrane transporter activity of SLC25A26 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11101882
displayName	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy
eventOf	[Pathway:R-SCE-549127] SLC-mediated transport of organic cations - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-2162188] COQ5 methylates MDMQ10H2 - Saccharomyces cerevisiae [Reaction:R-SCE-2162186] COQ3 methylates DeMQ10H2 - Saccharomyces cerevisiae [Reaction:R-SCE-2162193] COQ3 methylates DHDB - Saccharomyces cerevisiae [Reaction:R-SCE-6793591] LIAS synthesizes lipoyl-GCSH - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Homo sapiens
input	[SimpleEntity:R-ALL-2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-2162265] AdoMet [mitochondrial matrix]
precedingEvent	[Reaction:R-SCE-174391] MAT1A multimers transfer Ado from ATP to L-Met - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-8855062
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-549127] SLC-mediated transport of organic cations
(precedingEvent)	[Reaction:R-SCE-2162186] COQ3 methylates DeMQ10H2 [Reaction:R-SCE-2162188] COQ5 methylates MDMQ10H2 [Reaction:R-SCE-2162193] COQ3 methylates DHDB [Reaction:R-SCE-6793591] LIAS synthesizes lipoyl-GCSH
(inferredTo)	[Reaction:R-HSA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy