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Schema
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Entries
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
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authored
[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
created
[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
dbId
880009
displayName
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
edited
[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
eventOf
[Pathway:R-HSA-1428517] Aerobic respiration and respiratory electron transport - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:10930] 2-oxoglutarate metabolic process
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Homo sapiens
[Reaction:R-HSA-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Homo sapiens
[Reaction:R-HSA-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate - Homo sapiens
[Reaction:R-HSA-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2013-03-31
literatureReference
[LiteratureReference:879979] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
[LiteratureReference:881880] An integrated genomic analysis of human glioblastoma multiforme
[LiteratureReference:880063] D-2-Hydroxyglutaric aciduria: unravelling the biochemical pathway and the genetic defect
maxDepth
2
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
orthologousEvent
[Pathway:R-MMU-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Mus musculus
[Pathway:R-CFA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Canis familiaris
[Pathway:R-RNO-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Rattus norvegicus
[Pathway:R-SCE-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Saccharomyces cerevisiae
[Pathway:R-SPO-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Schizosaccharomyces pombe
[Pathway:R-DDI-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Dictyostelium discoideum
[Pathway:R-CEL-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Caenorhabditis elegans
[Pathway:R-DME-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Drosophila melanogaster
[Pathway:R-GGA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Gallus gallus
[Pathway:R-XTR-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Xenopus tropicalis
[Pathway:R-DRE-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Danio rerio
[Pathway:R-SSC-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Sus scrofa
[Pathway:R-BTA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Bos taurus
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1004534] Jassal, B, 2010-11-09
[InstanceEdit:1181204] Rush, MG, 2011-01-31
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-880009
summation
[Summation:880062] The two stereoisomers of 2-hydroxyglutarate are normally con...
updateTrackers
[UpdateTracker:9787748] Update Tracker - [Pathway:880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - v44:[modifyText, removeHasEvent]
[UpdateTracker:9790009] Update Tracker - [Pathway:880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - v36:[modifyText, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9787748] Update Tracker - [Pathway:880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - v44:[modifyText, removeHasEvent]
[UpdateTracker:9790009] Update Tracker - [Pathway:880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - v36:[modifyText, updateContainedRLE]
(hasEncapsulatedEvent)
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
(hasEvent)
[Pathway:R-HSA-1428517] Aerobic respiration and respiratory electron transport
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