Reactome | (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2

Schema > Reaction > Entries

(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 Show undefined attributes

authored	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
catalystActivity	[CatalystActivity:880022] (R)-2-hydroxyglutarate dehydrogenase activity of D2HGDH [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643378] (R)-2-hydroxyglutarate dehydrogenase activity of D2HGDH [mitochondrial matrix] Identification of a dehydrogenase acting on D-2-hydroxyglutarate
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
crossReference	[DatabaseIdentifier:12667735] RHEA:57169
dbId	880007
displayName	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
edited	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
eventOf	[Pathway:R-HSA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Homo sapiens
input	[SimpleEntity:R-ALL-879997] 2HG [mitochondrial matrix] [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:880023] Identification of a dehydrogenase acting on D-2-hydroxyglutarate [LiteratureReference:880012] Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias [LiteratureReference:880024] D-2-hydroxyglutaric acidaemia: identification of a new enzyme, D-2-hydroxyglutarate dehydrogenase, localized in mitochondria
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
negativePrecedingEvent	[NegativePrecedingEvent:9968593] Futile Cycle: 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
orthologousEvent	[Reaction:R-MMU-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Mus musculus [Reaction:R-SCE-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Saccharomyces cerevisiae [Reaction:R-SPO-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Schizosaccharomyces pombe [Reaction:R-DDI-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Dictyostelium discoideum [Reaction:R-CEL-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Caenorhabditis elegans [Reaction:R-DME-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Drosophila melanogaster [Reaction:R-GGA-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Gallus gallus [Reaction:R-XTR-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Xenopus tropicalis [Reaction:R-DRE-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Danio rerio [Reaction:R-SSC-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Sus scrofa [Reaction:R-BTA-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Bos taurus [Reaction:R-CFA-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Canis familiaris [Reaction:R-RNO-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Rattus norvegicus
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix]
regulatedBy	[PositiveRegulation:R-HSA-880065] Positive regulation by 'Zn2+ [mitochondrial matrix]' [PositiveRegulation:R-HSA-880066] Positive regulation by 'Co2+ [mitochondrial matrix]' [PositiveRegulation:R-HSA-880068] Positive regulation by 'Mn2+ [mitochondrial matrix]'
regulationReference	[RegulationReference:9642051] Positive regulation by 'Zn2+ [mitochondrial matrix]' Identification of a dehydrogenase acting on D-2-hydroxyglutarate [RegulationReference:9642140] Positive regulation by 'Mn2+ [mitochondrial matrix]' Identification of a dehydrogenase acting on D-2-hydroxyglutarate [RegulationReference:9642944] Positive regulation by 'Co2+ [mitochondrial matrix]' Identification of a dehydrogenase acting on D-2-hydroxyglutarate
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:1181204] Rush, MG, 2011-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-880007
summation	[Summation:880035] D2HDGH associated with the mitochondrial inner membrane cata...
updateTrackers	[UpdateTracker:9789987] Update Tracker - [Reaction:880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - v36:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789987] Update Tracker - [Reaction:880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - v36:[modifyText]
(hasEvent)	[Pathway:R-HSA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
(precedingEvent)	[NegativePrecedingEvent:9968590] Futile Cycle: (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2

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