Reactome | 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde

Schema > Reaction > Entries

2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde Show undefined attributes

authored	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
catalystActivity	[CatalystActivity:880047] hydroxyacid-oxoacid transhydrogenase activity of ADHFE1(1-?) [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643304] hydroxyacid-oxoacid transhydrogenase activity of ADHFE1(1-?) [mitochondrial matrix] Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
crossReference	[DatabaseIdentifier:11880946] Rhea:24735
dbId	880033
displayName	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
edited	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
eventOf	[Pathway:R-HSA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-880041] HBUT [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:880028] Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria [LiteratureReference:880012] Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
orthologousEvent	[Reaction:R-DDI-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Dictyostelium discoideum [Reaction:R-CEL-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Caenorhabditis elegans [Reaction:R-DME-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Drosophila melanogaster [Reaction:R-GGA-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Gallus gallus [Reaction:R-XTR-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Xenopus tropicalis [Reaction:R-DRE-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Danio rerio [Reaction:R-SSC-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Sus scrofa [Reaction:R-BTA-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Bos taurus [Reaction:R-CFA-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Canis familiaris [Reaction:R-RNO-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Rattus norvegicus [Reaction:R-MMU-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Mus musculus
output	[SimpleEntity:R-ALL-879997] 2HG [mitochondrial matrix] [SimpleEntity:R-ALL-880046] SUCCSA [mitochondrial matrix]
releaseDate	2010-12-14
reverseReaction	[Reaction:R-HSA-880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:1181204] Rush, MG, 2011-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-880033
summation	[Summation:880021] ADHFE1 catalyzes the reversible reaction of 2-oxoglutarate a...

Referrals

(hasEvent)

[Pathway:R-HSA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate