Reactome | (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2

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(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 Show undefined attributes

authored	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
catalystActivity	[CatalystActivity:880037] 2-hydroxyglutarate dehydrogenase activity of L2HGDH [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9643344] 2-hydroxyglutarate dehydrogenase activity of L2HGDH [mitochondrial inner membrane] The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
crossReference	[DatabaseIdentifier:11880119] Rhea:30088
dbId	880050
displayName	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
edited	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
eventOf	[Pathway:R-HSA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Homo sapiens
input	[SimpleEntity:R-ALL-880013] (S)-2HG [mitochondrial matrix] [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:880025] A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria [LiteratureReference:879998] The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase [LiteratureReference:880030] L-2-Hydroxyglutaric aciduria: identification of a mutant gene C14orf160, localized on chromosome 14q22.1
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
orthologousEvent	[Reaction:R-RNO-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Rattus norvegicus [Reaction:R-DDI-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Dictyostelium discoideum [Reaction:R-CEL-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Caenorhabditis elegans [Reaction:R-DME-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Drosophila melanogaster [Reaction:R-GGA-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Gallus gallus [Reaction:R-XTR-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Xenopus tropicalis [Reaction:R-SSC-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Sus scrofa [Reaction:R-BTA-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Bos taurus [Reaction:R-CFA-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Canis familiaris [Reaction:R-MMU-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Mus musculus
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix]
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:1181204] Rush, MG, 2011-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-880050
summation	[Summation:880036] L2HDGH associated with the mitochondrial inner membrane cata...

Referrals

(hasEvent)

[Pathway:R-HSA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate