Reactome | SOCS3 [cytosol]

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SOCS3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-8848108] p-Y342-PTK6:SOCS3 [cytosol] - Homo sapiens [Complex:R-HSA-1112718] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8848110] SOCS3 binds activated PTK6 - Homo sapiens [Reaction:R-HSA-2672302] Phosphorylated LEPR Binds SOCS3 - Homo sapiens [Reaction:R-HSA-2672302] Phosphorylated LEPR Binds SOCS3 - Homo sapiens [Reaction:R-HSA-1112755] SOCS3 binds IL6ST - Homo sapiens
created	[InstanceEdit:873796] Garapati, P V, 2010-06-08
dbId	873794
displayName	SOCS3 [cytosol]
endCoordinate	225
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-1169197] Socs3 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-873794] Socs3 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-873794] SOCS3 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-873794] SOCS3 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-873794] SOCS3 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-873794] socs3b [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-873794] socs3 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-873794] SOCS3 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-GGA-873794-2] SOCS3 [cytosol] - Gallus gallus [DefinedSet:R-GGA-873794-3] Homologues of SOCS3 [cytosol] - Gallus gallus
maxDepth	1
memberOf	[DefinedSet:R-HSA-6790032] STAT3-upregulated cytosolic proteins [cytosol] - Homo sapiens [CandidateSet:R-HSA-1169199] SOCS [cytosol] - Homo sapiens [DefinedSet:R-HSA-1169189] CIS, SOCS1-3 [cytosol] - Homo sapiens [DefinedSet:R-HSA-8863155] CUL5-box protein [cytosol] - Homo sapiens
name	SOCS3 Suppressor of cytokine signaling 3 SOCS3_HUMAN
producedByEvent	[BlackBoxEvent:R-HSA-9705458] p-Y-STAT1,3,5 dimer enhances expression of SOCS3 - Homo sapiens [BlackBoxEvent:R-HSA-8955885] SOCS3 gene expression is inhibited by RUNX1 - Homo sapiens [BlackBoxEvent:R-HSA-8848178] STAT3 stimulates SOCS3 expression - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:O14543] UniProt:O14543 SOCS3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-873794
startCoordinate	1

Referrals

(input)	[Reaction:R-HSA-2672302] Phosphorylated LEPR Binds SOCS3 [Reaction:R-HSA-1112755] SOCS3 binds IL6ST [Reaction:R-HSA-8848110] SOCS3 binds activated PTK6
(hasMember)	[DefinedSet:R-HSA-6790032] STAT3-upregulated cytosolic proteins [cytosol] [CandidateSet:R-HSA-1169199] SOCS [cytosol] [DefinedSet:R-HSA-1169189] CIS, SOCS1-3 [cytosol] [DefinedSet:R-HSA-8863155] CUL5-box protein [cytosol] [DefinedSet:R-HSA-877267] SOCS-1 and SOCS-3 [cytosol]
(output)	[BlackBoxEvent:R-HSA-9705458] p-Y-STAT1,3,5 dimer enhances expression of SOCS3 [BlackBoxEvent:R-HSA-8955885] SOCS3 gene expression is inhibited by RUNX1 [BlackBoxEvent:R-HSA-8848178] STAT3 stimulates SOCS3 expression
(hasComponent)	[Complex:R-HSA-1112718] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] [Complex:R-HSA-2672301] LEP:p-LEPR:p-JAK2:SOCS3 [plasma membrane] [Complex:R-HSA-8848108] p-Y342-PTK6:SOCS3 [cytosol]

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