Reactome | TNF signaling

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TNF signaling Show undefined attributes

authored	[InstanceEdit:140936] Gillespie, ME, 2004-08-24 21:32:45
created	[InstanceEdit:110071] Tschopp, J�rg, 2004-01-28
crossReference	[DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	75893
displayName	TNF signaling
doi	10.3180/R-HSA-75893.7
edited	[InstanceEdit:5692557] Shamovsky, Veronica, 2015-05-12
eventOf	[Pathway:R-HSA-73887] Death Receptor Signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:261164] tumor necrosis factor-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-3371385] TNF-? is cleaved by ADAM17 (TACE) - Homo sapiens [Reaction:R-HSA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Homo sapiens [Reaction:R-HSA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Homo sapiens [Reaction:R-HSA-3371353] Soluble TNF-? binds TNFR1 - Homo sapiens [Reaction:R-HSA-83660] Membrane-anchored TNF-? binds TNFR1 - Homo sapiens [Reaction:R-HSA-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Homo sapiens [Pathway:R-HSA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Homo sapiens [Pathway:R-HSA-5357786] TNFR1-induced proapoptotic signaling - Homo sapiens [Pathway:R-HSA-5626978] TNFR1-mediated ceramide production - Homo sapiens [Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:140939] TNF-R1 signaling: a beautiful pathway
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TNF signaling
orthologousEvent	[Pathway:R-CFA-75893] TNF signaling - Canis familiaris [Pathway:R-BTA-75893] TNF signaling - Bos taurus [Pathway:R-SSC-75893] TNF signaling - Sus scrofa [Pathway:R-DRE-75893] TNF signaling - Danio rerio [Pathway:R-XTR-75893] TNF signaling - Xenopus tropicalis [Pathway:R-GGA-75893] TNF signaling - Gallus gallus [Pathway:R-DME-75893] TNF signaling - Drosophila melanogaster [Pathway:R-CEL-75893] TNF signaling - Caenorhabditis elegans [Pathway:R-PFA-75893] TNF signaling - Plasmodium falciparum [Pathway:R-RNO-75893] TNF signaling - Rattus norvegicus [Pathway:R-MMU-75893] TNF signaling - Mus musculus
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25
revised	[InstanceEdit:3632873] Shamovsky, V, 2013-05-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75893
summation	[Summation:140942] The inflammatory cytokine tumor necrosis factor alpha (TNF-?...
updateTrackers	[UpdateTracker:9784184] Update Tracker - [Pathway:75893] TNF signaling - v54:[addHasEvent, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777003] Update Tracker - [Pathway:75893] TNF signaling - v73:[updateIndirectRLE] [UpdateTracker:9787460] Update Tracker - [Pathway:75893] TNF signaling - v45:[addHasEvent, updateContainedRLE] [UpdateTracker:9786611] Update Tracker - [Pathway:75893] TNF signaling - v49:[removeHasEvent, updateContainedRLE] [UpdateTracker:9785530] Update Tracker - [Pathway:75893] TNF signaling - v52:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9782507] Update Tracker - [Pathway:75893] TNF signaling - v59:[modifyText] [UpdateTracker:9787547] Update Tracker - [Pathway:75893] TNF signaling - v44:[updateContainedRLE] [UpdateTracker:9846662] Update Tracker - [Pathway:75893] TNF signaling - v84:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9846825] Update Tracker - [Pathway:75893] TNF signaling - v83:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783287] Update Tracker - [Pathway:75893] TNF signaling - v57:[modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9789393] Update Tracker - [Pathway:75893] TNF signaling - v38:[addLiteratureReference] [UpdateTracker:9785597] Update Tracker - [Pathway:75893] TNF signaling - v51:[removeHasEvent] [UpdateTracker:9864313] Update Tracker - [Pathway:75893] TNF signaling - v88:[modifyText] [UpdateTracker:9784584] Update Tracker - [Pathway:75893] TNF signaling - v53:[modifyText, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788277] Update Tracker - [Pathway:75893] TNF signaling - v43:[updateContainedRLE] [UpdateTracker:9846988] Update Tracker - [Pathway:75893] TNF signaling - v82:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9776733] Update Tracker - [Pathway:75893] TNF signaling - v74:[modifyText, updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-73887] Death Receptor Signaling
(hasEncapsulatedEvent)	[Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway [Pathway:R-HSA-140534] Caspase activation via Death Receptors in the presence of ligand
(updatedInstance)	[UpdateTracker:9784184] Update Tracker - [Pathway:75893] TNF signaling - v54:[addHasEvent, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777003] Update Tracker - [Pathway:75893] TNF signaling - v73:[updateIndirectRLE] [UpdateTracker:9787460] Update Tracker - [Pathway:75893] TNF signaling - v45:[addHasEvent, updateContainedRLE] [UpdateTracker:9786611] Update Tracker - [Pathway:75893] TNF signaling - v49:[removeHasEvent, updateContainedRLE] [UpdateTracker:9785530] Update Tracker - [Pathway:75893] TNF signaling - v52:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9782507] Update Tracker - [Pathway:75893] TNF signaling - v59:[modifyText] [UpdateTracker:9787547] Update Tracker - [Pathway:75893] TNF signaling - v44:[updateContainedRLE] [UpdateTracker:9846662] Update Tracker - [Pathway:75893] TNF signaling - v84:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9846825] Update Tracker - [Pathway:75893] TNF signaling - v83:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783287] Update Tracker - [Pathway:75893] TNF signaling - v57:[modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9789393] Update Tracker - [Pathway:75893] TNF signaling - v38:[addLiteratureReference] [UpdateTracker:9785597] Update Tracker - [Pathway:75893] TNF signaling - v51:[removeHasEvent] [UpdateTracker:9864313] Update Tracker - [Pathway:75893] TNF signaling - v88:[modifyText] [UpdateTracker:9784584] Update Tracker - [Pathway:75893] TNF signaling - v53:[modifyText, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788277] Update Tracker - [Pathway:75893] TNF signaling - v43:[updateContainedRLE] [UpdateTracker:9846988] Update Tracker - [Pathway:75893] TNF signaling - v82:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9776733] Update Tracker - [Pathway:75893] TNF signaling - v74:[modifyText, updateContainedPathway, updateIndirectRLE]

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