Reactome | Regulation of TNFR1 signaling

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Regulation of TNFR1 signaling Show undefined attributes

authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
crossReference	[DatabaseIdentifier:12325416] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12325418] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
dbId	5357905
displayName	Regulation of TNFR1 signaling
doi	10.3180/R-HSA-5357905.6
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
eventOf	[Pathway:R-HSA-75893] TNF signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:383947] regulation of tumor necrosis factor-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-8863101] SPPL2a/b cleaves TNF(1-76) - Homo sapiens [Reaction:R-HSA-5626953] TNF-?:TNFR1 binds DENN/MADD - Homo sapiens [Reaction:R-HSA-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex - Homo sapiens [BlackBoxEvent:R-HSA-5634228] TRAF1 is cleaved by caspases - Homo sapiens [BlackBoxEvent:R-HSA-5357828] RIPK1 is cleaved by CASP8 - Homo sapiens [Reaction:R-HSA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Homo sapiens [BlackBoxEvent:R-HSA-9697747] Caspase-8 and FLIP(L) processing at TNFR signaling complex - Homo sapiens [BlackBoxEvent:R-HSA-9697750] RIPK1 is cleaved by CASP8:FLIP(L) - Homo sapiens [Reaction:R-HSA-2672196] Viral serpin blocks caspase-8 activity - Homo sapiens [Reaction:R-HSA-5692550] Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 - Homo sapiens [Reaction:R-HSA-5626962] GNB2L1 binds IKKA:IKKB:NEMO - Homo sapiens [Reaction:R-HSA-5693055] TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes - Homo sapiens [Reaction:R-HSA-5693108] TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains - Homo sapiens [Reaction:R-HSA-5357928] CLIP3 and CYLD bind TNF signaling complex - Homo sapiens [BlackBoxEvent:R-HSA-5357845] K63polyUb-RIPK1 is deubiquitinated - Homo sapiens [Reaction:R-HSA-5661517] LUBAC binds OTULIN - Homo sapiens [BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Homo sapiens [Reaction:R-HSA-9796691] SPATA2 links CYLD to LUBAC - Homo sapiens [Reaction:R-HSA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Homo sapiens [BlackBoxEvent:R-HSA-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Homo sapiens [Reaction:R-HSA-9794008] LUBAC binds CFLAR - Homo sapiens [BlackBoxEvent:R-HSA-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Homo sapiens [BlackBoxEvent:R-HSA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Homo sapiens [BlackBoxEvent:R-HSA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Homo sapiens [Reaction:R-HSA-9796368] RIPK1 binds STUB1 - Homo sapiens [BlackBoxEvent:R-HSA-9796387] STUB1 ubiquitinates RIPK1 at K571, K604, K627 - Homo sapiens [Reaction:R-HSA-9796342] MIB2 binds RIPK1 within TNF-?:TNFR1:TRADD:RIPK1:TRAF2 - Homo sapiens [BlackBoxEvent:R-HSA-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634 - Homo sapiens [Reaction:R-HSA-9815510] MIB2 binds CYLD - Homo sapiens [BlackBoxEvent:R-HSA-9815507] MIB2 ubiquitinates CYLD at K338, K530 - Homo sapiens [Reaction:R-HSA-9796617] MIB2 binds CFLAR - Homo sapiens [BlackBoxEvent:R-HSA-9796626] MIB2 ubiquitinates CFLAR - Homo sapiens [Reaction:R-HSA-9815501] MAPKAPK2 phosphorylates RIPK1 at S320 - Homo sapiens [Reaction:R-HSA-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex - Homo sapiens [Reaction:R-HSA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189 - Homo sapiens [Reaction:R-HSA-9819106] ULK1 phosphorylates RIPK1 at S357 - Homo sapiens [Reaction:R-HSA-9818789] CHUK, IKBKB phosphorylate RIPK1 at S25 - Homo sapiens [Reaction:R-HSA-5357831] CHUK, IKBKB phosphorylate CYLD at S418 - Homo sapiens [Reaction:R-HSA-9793680] OPTN binds polyUb-RIPK1 within the TNFR1 complex - Homo sapiens [Reaction:R-HSA-9824874] OPTN recruits CYLD to the TNFR1 complex - Homo sapiens [Reaction:R-HSA-9823816] OPTN binds CASP8 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5357806] Regulation of NF-?B by deubiquitinases [LiteratureReference:213426] Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1 [LiteratureReference:213424] Regulation of apoptosis: the ubiquitous way
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Regulation of TNFR1 signaling
orthologousEvent	[Pathway:R-CEL-5357905] Regulation of TNFR1 signaling - Caenorhabditis elegans [Pathway:R-DME-5357905] Regulation of TNFR1 signaling - Drosophila melanogaster [Pathway:R-GGA-5357905] Regulation of TNFR1 signaling - Gallus gallus [Pathway:R-XTR-5357905] Regulation of TNFR1 signaling - Xenopus tropicalis [Pathway:R-DRE-5357905] Regulation of TNFR1 signaling - Danio rerio [Pathway:R-SSC-5357905] Regulation of TNFR1 signaling - Sus scrofa [Pathway:R-BTA-5357905] Regulation of TNFR1 signaling - Bos taurus [Pathway:R-MMU-5357905] Regulation of TNFR1 signaling - Mus musculus [Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus [Pathway:R-CFA-5357905] Regulation of TNFR1 signaling - Canis familiaris
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5357905
summation	[Summation:5433114] Tumor necrosis factor-alpha (TNF?) is an inflammatory cytoki...

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[Pathway:R-HSA-75893] TNF signaling

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