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Schema
>
Reaction
>
Entries
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
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authored
[InstanceEdit:140952] Gillespie, ME, 2004-08-24 21:33:15
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:110071] Tschopp, Jürg, 2004-01-28
dbId
83656
displayName
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
edited
[InstanceEdit:3371404] Shamovsky, V, 2013-05-13
eventOf
[Pathway:R-HSA-75893] TNF signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Homo sapiens
[Reaction:R-HSA-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-168651] RIPK1 [cytosol]
[DefinedSet:R-HSA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane]
3 ×
[EntityWithAccessionedSequence:R-HSA-66376] TRADD [cytosol]
3 ×
[EntityWithAccessionedSequence:R-HSA-66370] TRAF2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:140948] The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
maxDepth
1
modified
[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
orthologousEvent
[Reaction:R-DRE-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Danio rerio
[Reaction:R-SSC-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Sus scrofa
[Reaction:R-BTA-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Bos taurus
[Reaction:R-CFA-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Canis familiaris
[Reaction:R-RNO-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Rattus norvegicus
[Reaction:R-MMU-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Mus musculus
[Reaction:R-DME-209221] Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' - Drosophila melanogaster
[Reaction:R-DME-214405] Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' - Drosophila melanogaster
output
[Complex:R-HSA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-83660] Membrane-anchored TNF-? binds TNFR1 - Homo sapiens
[Reaction:R-HSA-3371353] Soluble TNF-? binds TNFR1 - Homo sapiens
releaseDate
2004-10-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
revised
[InstanceEdit:3465563] Shamovsky, V, 2013-05-17
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-83656
summation
[Summation:74302] Once the TNF-?:TNFR1:TRADD:RIPK1 complex has been formed the...
updateTrackers
[UpdateTracker:9784647] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v53:[modifyText]
[UpdateTracker:9784866] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v52:[modifyText]
[UpdateTracker:9787345] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v45:[add_removeInput]
[UpdateTracker:9784273] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v54:[modifyText]
[UpdateTracker:9787949] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v44:[addRegulator, add_removeInput]
[UpdateTracker:9847052] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v82:[modifyText]
[UpdateTracker:9786460] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v49:[removeRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9784647] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v53:[modifyText]
[UpdateTracker:9784866] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v52:[modifyText]
[UpdateTracker:9787345] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v45:[add_removeInput]
[UpdateTracker:9784273] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v54:[modifyText]
[UpdateTracker:9787949] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v44:[addRegulator, add_removeInput]
[UpdateTracker:9847052] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v82:[modifyText]
[UpdateTracker:9786460] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v49:[removeRegulator]
(hasEvent)
[Pathway:R-HSA-75893] TNF signaling
(precedingEvent)
[Reaction:R-HSA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
[Reaction:R-HSA-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1
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